Endocrine Abstracts

Introduction: Medullary thyroid cancer (MTC) TNM classification categorizes lymph nodes (LN) according to their location, but does not consider number and size of LN.Objective: To analyze the relationship between number and size of LN in MCT persistent disease (PD).Material and methods: Retrospective study of patients with MTC followed up in a regional hospital from 1985 to 2015. The main variables (expressed as qualitative in freq...

Introduction: Tyrosine kinase inhibitors (TKIs) are used for treatment of iodine-refractory differentiated thyroid cancer (DTC) in patients with progressive advanced disease.Sorafenib and lenvatinib are the TKIs currently approved for this indication.Objective: To describe the clinical experience in patients with iodine-refractory DTC treated with TKIs in our Institution.Materials and methods: Restrospective cohort study of patient...

Introduction: Abnormal glucose metabolism (AGM) is the most common extra-pulmonary comorbidity in people with cystic fibrosis (CF) and has a high negative impact on the underlying disease. Elevated postprandial glucose level is usually the first manifestation, which is traditionally detected by 75-gram oral glucose tolerance test (OGTT). The aim of this study was to evaluate glycemic pattern during continuous glucose monitoring (CGM) in patients with impaired glucose metabolis...

Introduction: Lenvatinib is an oral tyrosine kinase inhibitor (TKI) used for treatment of progressive, clinically significant or symptomatic disease in patients with iodine-refractory differentiated thyroid cancer (DTC).Objective: To describe our clinical experience with lenvatinib in patients with iodine-refractory differentiated thyroid cancer.Methods: Restrospective cohort study of patients with iodine-refractory differentiated ...

Introduction: One of the main difficulties in the study of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is their wide heterogeneity and variable outcome. Several potential influencing factors on patient survival have been recently identified. These factors could help predict patients’ prognosis.Objectives: Analysis of long-term survival of our GEP-NETs cohort according to the presence of metastatic disease, tumor grade, age, sex, tumor fu...

Introduction: GH deficiency (GHD) leads to altered body composition, lipid metabolism and quality of life, and is also associated to an increased cardiovascular morbidity and mortality. The aim of this study was to evaluate long-term changes after treatment with GH replacement therapy (GHRT).Methods: We retrospectively reviewed adult patients with GHD in our clinic who were treated with GHRT. We evaluated demographic (etiology, age, dose), anthropometric...

Context: T regulatory type 1 (Tr1) cells are a subpopulation of T lymphocytes (CD4+CD49+LAG-3+IL-10+) lymphocytes that exerts a significant immunosuppressive effect. However, its possible role in autoimmune thyroid disease (AITD) had not been explored so far.Objective: To analyze the levels and function of Tr1 cells in peripheral blood and thyroid tissue of patients with AITD.Design: Cases and controls, observational study.<p c...

Introduction: Hydrocarbon Alteration (HA) is considered as the most common complication in Cystic Fibrosis (CF) and is related to a further deterioration of the lung function and the nutritional status.Objective: Analyze the prevalence of HA in patients with CF in an adult unit and its relationship with pulmonary complications.Material and methods: We conducted a retrospective study with 71 patients of our CF unit (age 30+/−9...

Introduction: Surgery is the treatment of choice for non-functioning pituitary adenomas (NFPA), but remnants are frequently observed. Management of these remnants include observation (OBS), radiotherapy (RT) and/or dopamine agonist (DA) therapy. In this study, we evaluate the progression-free survival (PFS) of NFPA with postoperative remnant and the potential factors involved.Methods: We performed a single-center ambispective study of a cohort of 72 pati...

Introduction: The incidence of papillary thyroid microcarcinomas (MPT, max diameter≤10 mm) has increased in recent years. Most have a very good prognosis but some have growth during follow-up, lymph node and / or distant metastases.Material and methods: We performed a single-center, retrospective cohort study, n=114 patients (86% women, average age 48.3 years), diagnosed with MPT between 1998 and 2012. Risk stratification system (ATA 2015): 10 high...